Introducing intermediate filaments: From discovery to disease

John E. Eriksson, Thomas Dechat, Boris Grin, Brian Helfand, Melissa Mendez, Hanna Mari Pallari, Robert D. Goldman

Research output: Contribution to journalReview article

245 Scopus citations

Abstract

It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus. However, during the past 2 decades, knowledge regarding the functions of these structures has been expanding rapidly. Many disease-related roles of IFs have been revealed. In some cases, the molecular mechanisms underlying these diseases reflect disturbances in the functions traditionally assigned to IFs, i.e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years.

Original languageEnglish (US)
Pages (from-to)1763-1771
Number of pages9
JournalJournal of Clinical Investigation
Volume119
Issue number7
DOIs
StatePublished - Jul 1 2009

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Introducing intermediate filaments: From discovery to disease'. Together they form a unique fingerprint.

  • Cite this

    Eriksson, J. E., Dechat, T., Grin, B., Helfand, B., Mendez, M., Pallari, H. M., & Goldman, R. D. (2009). Introducing intermediate filaments: From discovery to disease. Journal of Clinical Investigation, 119(7), 1763-1771. https://doi.org/10.1172/JCI38339