Introduction and prospection of minimization random on clinical trials

Chun Fang Wu*, Jin Fang Xu, Jian Lu, Mei Jing Wu, Jia He

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Randomization is one of the most important aspects of clinical trial design, which is a good way to avoid bias in trials. As a dynamic randomization method, minimization random plays an unparalleled role in small heterogeneous trials, making well-balanced treatment groups with regard of patient numbers and important prognostic factors. The aims of this paper were to describe the basic process of minimization random, introduce some supplementary methods, summarize some related issues and also discuss the prospect of its future development.

Original languageEnglish (US)
Pages (from-to)823-826+831
JournalChinese Journal of New Drugs
Issue number10
StatePublished - 2010


  • Balance
  • Minimization random
  • Prognostic factor
  • Random factor

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)


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