Introduction of fast MR imaging in the assessment of hepatic steatosis

Mark H. Fishbein*, Kathryn G. Gardner, Carol J. Potter, Petra Schmalbrock, Mark A. Smith

*Corresponding author for this work

Research output: Contribution to journalArticle

187 Scopus citations

Abstract

We determined the utility of fast gradient echo techniques (modified Dixon method) in the assessment of hepatic fat content. Fast spoiled gradient echo was performed on bovine liver/corn oil homogenates with known fat fractions (FF(E)) to assess the accuracy of fat quantitation (FF(MRI)). The pulse sequence was manipulated via alterations in TE (echo time), TR (repetition time), and α (flip angle). In vivo studies were then performed using breath-holding maneuvers on normal adult volunteers and subjects at risk to develop hepatic steatosis, with cystic fibrosis or morbid obesity. At out-of-phase, TE, TR, and α were 2.1 ms, 7.3 ms, and 30-50°and in-phase TE, TR, and α were 4.2 ms, 9.3 ms, and 30-50°; FF(MRI) correlated well with FF(E). An elevated fat fraction was observed in a high percentage of subjects with cystic fibrosis and morbid obesity. Fast gradient echo techniques were used successfully in the assessment of hepatic steatosis. The reduced acquisition times permitted in vivo analysis on adults and children using breath hold maneuvers.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalMagnetic Resonance Imaging
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1997

Keywords

  • Dixon method
  • Fast spoiled gradient echo
  • Fat quantitation
  • Fatty liver

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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