Introduction of HIV type 1 subtype E virus into South Korea

Joo Shil Lee*, Jeong Gu Nam, Eun Young Kim, Chun Kang, Bon Ki Koo, Hae Wol Cho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Subtype E HIV-1 is the most prevalent strain in Southeast Asia. Although subtype B is prevalent in Korea, geographical distance and increases in travel may lead to the spread of subtype E in Korea. Therefore, we tried to identify and monitor the patterns of HIV subtype E virus introduction into Korea. The divergence of nucleotide sequences within the envelope region (V3 to V5) of Korean subtype E isolates ranged from 4.3 to 14.6% (n = 8; mean, 9.5 ± 2.8%). In pairwise comparisons of subtype E isolates between Korea and other regions, the divergence of nucleotide sequences between 8 Korean and 16 Asian subtype E variants ranged from 1.3 to 15.2% (mean, 7.8 ± 2.6%), whereas the divergence of nucleotide sequences between 8 Korean and 2 African variants ranged from 11.7 to 20.7% (mean, 15.4 ± 2.2%). A phylogenetic tree showed that Korean subtype E isolates cluster with the Asian isolates but far from the African isolates. These epidemiological and molecular epidemiological data suggest that HIV-1 subtype E strains have been transmitted into Korea from endemic areas of Southeast Asia rather from Africa.

Original languageEnglish (US)
Pages (from-to)1083-1087
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume16
Issue number11
DOIs
StatePublished - Jul 20 2000

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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