Introduction. Regenerative medicine and solid organ transplantation from a historical perspective.

Joseph P. Vacanti*, Jean Bernard Otte, Jason A Wertheim

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Regenerative medicine and transplantation are rooted in distinct but major scientific advancements during the last 15 and 50 years, respectively. To introduce this text, we review the major milestones that led to the development of solid organ transplantation and regenerative medicine. The success of transplantation has led to the need for regenerative medicine. The number of patients waiting for an organ for transplantation has surpassed 117,000. Many of these candidates may not receive an organ due to the limited supply of cadaveric grafts or those donated by altruistic living donors. It is the shared hope that regenerative medicine may one day augment organ transplantation by developing a new source of organs or potentially rehabilitating those that are not transplantable. This chapter summarizes major advancements in both fields including vascular reconstruction, organ preservation, immunosuppression, operational tolerance, novel stem cell sources, biodegradable scaffolds, and new methods to develop vascularized organ units.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages1-15
Number of pages15
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014

Keywords

  • Organ shortage
  • Regenerative medicine
  • Solid organ transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Vacanti, J. P., Otte, J. B., & Wertheim, J. A. (2014). Introduction. Regenerative medicine and solid organ transplantation from a historical perspective. In Regenerative Medicine Applications in Organ Transplantation (pp. 1-15). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00001-X