Intussusception in canine recipients of hematopoietic cell grafts and surgical correction

Murad Y. Yunusov, Fabio Kerbauy, Kraig Abrams, Eustacia Zellmer, Michele Spector, Christian S. Kuhr, Billanna Hwang, Barry Storer, George E. Georges, Benjamin J. Weigler, Rainer Storb, Richard A. Nash*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Intussusception is a common complication after canine hematopoietic cell transplantation (HCT). The present study was undertaken to evaluate predisposing factors of intussusception and to test whether intussusception can be managed surgically during the period immediately after HCT. We determined the incidence of intussusception after HCT was performed in 325 canine recipients (autologous, n = 43; allogeneic, n = 282) during the interval from January 2002 to May 2005. Intussusception was diagnosed in 16 of 325 dogs (4.9%). Intussusception was not significantly associated with the dose of irradiation, source of hematopoietic graft, use of immunosuppressive agents, gender, or age at transplant. A group of 9 of the affected dogs underwent small-bowel resection after diagnosis, and 7 were managed without surgical intervention. Despite complicating factors such as gastrointestinal toxicity and low neutrophil and platelet counts induced by the marrow conditioning regimen and the use of immunosuppressive agents, successful surgical management of intussusception was achieved in 6 of 9 dogs, as compared with successful management of 0 of 7 without surgery. Intussusception did not recur after surgical intervention in any dog. Recent HCT and post-transplant immunosuppressive therapy are not absolute contraindications to surgical intervention for intussusception in canine recipients of HCT.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalComparative Medicine
Volume57
Issue number3
StatePublished - Jun 2007

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary

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