Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk among Patients with Cardiogenic Shock

Katherine L. Thayer, Elric Zweck, Mohyee Ayouty, A. Reshad Garan, Jaime Hernandez-Montfort, Claudius Mahr, Kevin J. Morine, Sarah Newman, Lena Jorde, Jillian L. Haywood, Neil M. Harwani, Michele L. Esposito, Carlos D. Davila, Detlef Wencker, Shashank S. Sinha, Esther Vorovich, Jacob Abraham, William O'Neill, James Udelson, Daniel BurkhoffNavin K. Kapur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Risk stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) stages as an approach to identify patients at risk for in-hospital mortality remains under investigation. We studied the utility of the SCAI stages and further explored the impact of hemodynamic congestion on clinical outcomes. Methods: The CS Working Group registry includes patients with CS from 8 medical centers enrolled between 2016 and 2019. Patients were classified by the maximum SCAI stage (B-E) reached during their hospital stay according to drug and device utilization. In-hospital mortality was evaluated for association with SCAI stages and hemodynamic congestion. Results: Of the 1414 patients with CS, the majority were due to decompensated heart failure (50%) or myocardial infarction (MI; 35%). In-hospital mortality was 31% for the total cohort, but higher among patients with MI (41% versus 26%, MI versus heart failure, P<0.0001). Risk for in-hospital mortality was associated with increasing SCAI stage (odds ratio [95% CI], 3.25 [2.63-4.02]) in both MI and heart failure cohorts. Hemodynamic data was available in 1116 (79%) patients. Elevated biventricular filling pressures were common among patients with CS, and right atrial pressure was associated with increased mortality and higher SCAI Stage. Conclusions: Our findings support an association between the proposed SCAI staging system and in-hospital mortality among patient with heart failure and MI. We further identify that venous congestion is common and identifies patients with CS at high risk for in-hospital mortality. These findings provide may inform future management protocols and clinical studies.Â

Original languageEnglish (US)
Article numbere007099
Pages (from-to)334-349
Number of pages16
JournalCirculation: Heart Failure
DOIs
StateAccepted/In press - 2020
Externally publishedYes

Keywords

  • cardiogenic shock
  • heart failure
  • hemodynamics
  • hospital mortality
  • myocardial infarction
  • right atrial pressure
  • ventricular congestion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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