Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system

Connor J. Kinslow, Raj S. Rajpara, Cheng Chia Wu, Samuel S. Bruce, Peter D. Canoll, Shih Hsiu Wang, Adam M. Sonabend, Sameer A. Sheth, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Tony J.C. Wang*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Meningeal hemangiopericytoma (m-HPC) is a rare tumor of the central nervous system (CNS), which is distinguished clinically from meningioma by its tendency to recur and metastasize. The histological classification and grading scheme for m-HPC is still evolving and few studies have identified tumor features that are associated with metastasis. All patients at our institution with m-HPC were assessed for patient, tumor, and treatment characteristics associated with survival, recurrence, and metastasis. New findings were validated using the SEER database. Twenty-seven patients were identified in our institutional records with m-HPC with a median follow-up time of 85 months. Invasiveness was the strongest predictor of decreased overall survival (OS) and decreased metastasis-free survival (MFS) (p = 0.004 and 0.001). On subgroup analysis, bone invasion trended towards decreased OS (p = 0.056). Bone invasion and soft tissue invasion were significantly associated with decreased MFS (p = 0.001 and 0.012). An additional 315 patients with m-HPC were identified in the SEER database that had information on tumor invasion and 263 with information on distant metastasis. Invasion was significantly associated with decreased survival (HR = 5.769, p = 0.007) and metastasis (OR 134, p = 0.000) in the SEER data. In this study, the authors identified a previously unreported tumor characteristic, invasiveness, as the strongest factor associated with decreased survival and metastasis. The association of invasion with decreased survival and metastasis was confirmed in a separate, larger, publicly available database. Invasion may be a useful parameter in the histological grading and clinical management of hemangiopericytoma of the CNS.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalJournal of Neuro-Oncology
Volume133
Issue number2
DOIs
StatePublished - Jun 1 2017

Keywords

  • Central nervous system
  • Hemangiopericytoma
  • Invasiveness
  • Meningeal tumor

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Kinslow, C. J., Rajpara, R. S., Wu, C. C., Bruce, S. S., Canoll, P. D., Wang, S. H., Sonabend, A. M., Sheth, S. A., McKhann, G. M., Sisti, M. B., Bruce, J. N., & Wang, T. J. C. (2017). Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system. Journal of Neuro-Oncology, 133(2), 409-417. https://doi.org/10.1007/s11060-017-2450-8