We present an Inversed Temperature Dependence (ITD) aware clock skew scheduling framework. Specifically, we demonstrate how our framework can assist dual-Vth assignment in preventing timing violations arising due to ITD effect. We formulate the ITD aware synthesis problem and prove that it is NP-Hard. Then, we propose an algorithm for synergistic temperature aware clock skew scheduling and dual-Vth assignment. Experiments on ISCAS89 benchmarks reveal that several circuits synthesized by the traditional high-temperature corner based flow with a commercial tool exhibit timing violations in the low temperature range while all circuits generated using our methodology for the same timing constraints have guaranteed timing.