Investigating the extremes of antibiotic use with an epidemiologic framework

Marc H. Scheetz*, Page E. Crew, Cristina Miglis, Elise M. Gilbert, Sarah H. Sutton, J. Nick O'Donnell, Michael Postelnick, Teresa Zembower, Nathaniel J. Rhodes

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

8 Scopus citations


Benchmarks for judicious use of antimicrobials are needed. Metrics such as defined daily doses (DDDs) and days of therapy (DOTs) quantify antimicrobial consumption. However, benchmarking with these metrics is complicated by interhospital variability. Thus, it is important for each hospital to monitor its own temporal consumption trends. Time series analyses allow trends to be detected; however, many of these methods are complex. We present simple regressive methods and caveats in using them to define potential antibiotic over- and underutilizations.

Original languageEnglish (US)
Pages (from-to)3265-3269
Number of pages5
JournalAntimicrobial agents and chemotherapy
Issue number6
StatePublished - Jun 2016

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology


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