Investigation of the influence of body weight index to the result of therapeutic erythrocytapheresis in patients with polycythemia vera

Jie Bai, Lei Zhang, Xiao Hu, Yangping Xue, Fenglei Long, Bin Zhang, Shi Yan*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We investigated the correlation between body weight index (BWI) and the effective power of erythrocytapheresis in patients with polycythemia vera (PV) who received therapeutic erythrocytapheresis (TEA). Furthermore, the risk factors of the adverse events related to erythroapheresis therapy were analyzed. Two hundred and seventeen cycles of therapeutic erythrocytapheresis were carried out in 139 patients with PV (Hct). The correlation between the BWI and the difference of hematocrit before and after therapeutic erythrocytapheresis (ΔHct) was analyzed by the Pearson correlation analysis method. Logistic regression analysis was used to study the risk factors of adverse events for TEA. We observed a positive correlation between the BWI and ΔHct. BWI over 15. ml/kg, inlet velocity of the apheresis procedure over 45. ml/min and an age older than 50. years were the risk factors of adverse events of TEA. The results suggested that BWI was a sensitive index to estimate the effective power and adverse events of TEA. The rate of adverse events of TEA might be reduced by maintaining the BWI below the dangerous threshold of 15. ml/kg and the inlet velocity of the apheresis procedure below 45. ml/min especially in patients older than 50. years of age.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalTransfusion and Apheresis Science
Volume47
Issue number3
DOIs
StatePublished - Dec 2012

Keywords

  • Body weight index
  • Polycythemia vera
  • Reverse response
  • Therapeutic erythrocytapheresis

ASJC Scopus subject areas

  • Hematology

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