Invited review: Lung edema clearance: Role of Na+-K+-ATPase

J. I. Sznajder, P. Factor, D. H. Ingbar

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Acute hypoxemic respiratory failure is a consequence of edema accumulation due to elevation of pulmonary capillary pressures and/or increases in permeability of the alveolocapillary barrier. It has been recognized that lung edema clearance is distinct from edema accumulation and is largely effected by active Na+ transport out of the alveoli rather than reversal of the Starling forces, which control liquid flux from the pulmonary circulation into the alveolus. The alveolar epithelial Na+-K+-ATPase has an important role in regulating cell integrity and homeostasis. In the last 15 yr, Na+,K+-ATPase has been localized to the alveolar epithelium and its contribution to lung edema clearance has been appreciated. The importance of the alveolar epithelial Na+-K+-ATPase function is reflected in the changes in the lung's ability to clear edema when the Na+-K+-ATPase is inhibited or increased. An important focus of the ongoing research is the study of the mechanisms of Na+-K+-ATPase regulation in the alveolar epithelium during lung injury and how to accelerate lung edema clearance by modulating Na+-K+-ATPase activity.

Original languageEnglish (US)
Pages (from-to)1860-1866
Number of pages7
JournalJournal of applied physiology
Issue number5
StatePublished - Nov 1 2002


  • Acute respiratory distress syndrome
  • Alveolar epithelium
  • Ion transport

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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