Involutional and developmental implications of age-related neuronal changes: in search of an engram for wisdom

M. Marsel Mesulam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The changes in neuronal size and number that occur with aging can be viewed from a developmental rather than an involutional perspective. According to this speculative vantage point, age-related neuronal attrition need not lead to intellectual decline and may, instead, represent a progressive fine-tuning of cerebral networks.

Original languageEnglish (US)
Pages (from-to)581-583
Number of pages3
JournalNeurobiology of Aging
Issue number6
StatePublished - 1987

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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