Involvement of bradykinin-induced [Ca2+](i) oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts

T. Fu*, Y. Okano, Y. Nozawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Bradykinin (BK) induced a biphasic 1,2-diacylglycerol production in both K-ras-transformed (DT) cells and its parent NIH3T3 cells. The first phase was coincident with the transient phosphoinositide turnover and the second sustained phase was derived from hydrolysis of phosphatidylcholine (PC). In DT cells, the PC breakdown was considerably due to phospholipase C and dependent on intracellular calcium oscillations.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalAgents and Actions
Volume38
Issue numberSUPPL. II
StatePublished - 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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