Involvement of follicular stem cells in forming not only the follicle but also the epidermis

Gina Taylor, Michael S. Lehrer, Pamela J. Jensen, Tung Tien Sun*, Robert M. Lavker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

897 Scopus citations

Abstract

The location of follicular and epidermal stem cells mammalian skin is a crucial issue in cutaneous biology. We demonstrate that hair follicular stem cells, located in the bulge region, can give rise to several cell types of the hair follicle as well as upper follicular cells. Moreover, we devised a double-label technique to show that upper follicular keratinocytes emigrate into the epidermis in normal newborn mouse skin, and in adult mouse skin in response to a penetrating wound. These findings indicate that the hair follicle represents a major repository of keratinocyte stem cells in mouse skin, and that follicular bulge stem cells are potentially bipotent as they can give rise to not only the hair follicle, but also the epidermis.

Original languageEnglish (US)
Pages (from-to)451-461
Number of pages11
JournalCell
Volume102
Issue number4
DOIs
StatePublished - Aug 18 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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