Ion-channel-forming colicins

Robert M. Stroud*, Kinkead Reiling, Michael Wiener, Douglas Freymann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Several features of ion-channel-forming colicins have been illuminated by recent revelations: its four-domain structure, the mechanism and thermodynamics of binding to the gating loop of outer membrane porins, the mechanism of translocation, competition for the transperiplasmic excursion facilitated by the Tol or Ton transperiplasmic proteins, and the formation of a waisted, funnel-shaped transmembrane channel of well-characterized shape.

Original languageEnglish (US)
Pages (from-to)525-533
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume8
Issue number4
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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