Ion channels and transporters in lymphocyte function and immunity

Stefan Feske; Edward Y. Skolnik; Murali Prakriya

doi:10.1038/nri3233

Ion channels and transporters in lymphocyte function and immunity

Stefan Feske^*, Edward Y. Skolnik, Murali Prakriya

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

319 Scopus citations

Abstract

Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.

Original language	English (US)
Pages (from-to)	532-547
Number of pages	16
Journal	Nature Reviews Immunology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/nri3233
State	Published - Jul 2012

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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@article{e535ce21d20a41ff878199173f552aaf,

title = "Ion channels and transporters in lymphocyte function and immunity",

abstract = "Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.",

author = "Stefan Feske and Skolnik, {Edward Y.} and Murali Prakriya",

note = "Funding Information: We thank H. Wulff, B. N. Desai and H. McBride for their critical reading of the manuscript and their insightful comments. This work was supported in part by US National Institutes of Health grants AI066128 (to S.F.), NS057499 (to M.P.) and GM084195 (to E.Y.S.).",

year = "2012",

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doi = "10.1038/nri3233",

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AU - Feske, Stefan

AU - Skolnik, Edward Y.

AU - Prakriya, Murali

N1 - Funding Information: We thank H. Wulff, B. N. Desai and H. McBride for their critical reading of the manuscript and their insightful comments. This work was supported in part by US National Institutes of Health grants AI066128 (to S.F.), NS057499 (to M.P.) and GM084195 (to E.Y.S.).

PY - 2012/7

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N2 - Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.

AB - Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.

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Ion channels and transporters in lymphocyte function and immunity

Abstract

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