@article{ca54b2831f6a40c5a7f163b7553bd65c,
title = "Ion permeation and selectivity of squid axon sodium channels modified by tetramethrin",
abstract = "The pyrethroid tetramethrin greatly prolongs the sodium current during step depolarization and the sodium tail current associated with step repolarization of the squid axon membrane. Non-linear current-voltage relationships for the sodium tail current were analyzed to assess the open sodium channel properties which included the permeation of various cations, calcium block and cation selectivity. Tetramethrin had no effect on any of these properties. It was concluded that tetramethrin modifies the sodium channel gating machinery without affecting the pore properties.",
keywords = "ion permeation, ion selectivity, pyrethroid, sodium channel, tetramethrin",
author = "Daisuke Yamamoto and Yeh, {Jay Z.} and Toshio Narahashi",
note = "Funding Information: This work was supportedb y NIH Grant NS14143. We thank SumitomoC hemicalC ompany(Takarazu-ka, Japan) for their generouss upplyof (+)-trans-te- 1 Baker,P .F., Hodgkin,A .L. and Shaw,T .I., Replacement of the protoplasmof a giantn ervef ibrewith artificiasl olu-tions,N ature( London),1 90( 1961)8 85-887. 2 BezanillaF, . and ArmstrongC, .M., Inactivatioonf the so-dium channel.I . Sodium currente xperimentsJ., Gen. Physiol.,7 0( 1977)5 49-566. 3 CampbellD, .T., Modifiedk ineticsa nd selectivitoyf sodi-um channelisn frog skeletaml usclefi berst reatedw ithaco-nitineJ,. Gen. Physiol.,8 0 (1982)7 13-731. 4 Chandler,W .K. and Meves, H., Voltage clamp experi-mentso n internallyp erfusedg ianta xonsJ,. Physiol. (Lon-don), 180( 1965)7 88-820. 5 GoldmanD, .E., Potentiali,m pedancaen d rectificatioinn membraneJs. ,Gen. Physiol.,2 7 (1943)3 7-60. 6 Hille, B., The permeabilitoyf the sodiumc hannetlo organ-ic cationsin myelinatende rve,J. Gen. Physiol.,5 8 (1971) 599-619.",
year = "1986",
month = apr,
day = "30",
doi = "10.1016/0006-8993(86)91478-2",
language = "English (US)",
volume = "372",
pages = "193--197",
journal = "Brain research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}