Ion permeation and selectivity of squid axon sodium channels modified by tetramethrin

Daisuke Yamamoto, Jay Z. Yeh, Toshio Narahashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The pyrethroid tetramethrin greatly prolongs the sodium current during step depolarization and the sodium tail current associated with step repolarization of the squid axon membrane. Non-linear current-voltage relationships for the sodium tail current were analyzed to assess the open sodium channel properties which included the permeation of various cations, calcium block and cation selectivity. Tetramethrin had no effect on any of these properties. It was concluded that tetramethrin modifies the sodium channel gating machinery without affecting the pore properties.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalBrain research
Volume372
Issue number1
DOIs
StatePublished - Apr 30 1986

Keywords

  • ion permeation
  • ion selectivity
  • pyrethroid
  • sodium channel
  • tetramethrin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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