Ionic and electrophysiological properties of retinal Müller (glial) cells of the turtle.

J. D. Conner*, P. B. Detwiler, P. V. Sarthy

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The ionic and electrophysiological properties of Müller cells, the principal glial element of the vertebrate retina, were investigated. The membrane potential of enzymatically dissociated and in situ Müller cells was about ‐80 mV and depended on external K+ concentration in a manner that was described by the Goldman‐Hodgkin‐Katz equation with a Na+‐K+ permeability ratio of 0.037. The current‐voltage relation showed marked inward rectification, with the input resistance at the resting potential being about 30 M omega for dissociated cells and about 3 M omega for in situ cells. In situ Müller cells were found to be electrically coupled to each other which could explain their lower resistance. We conclude that Müller cells are similar to other types of glia. In spite of a finite Na+ permeability their membrane potential is determined mainly by K+, they are electrically inexcitable and form an electrically coupled network in the retina.

Original languageEnglish (US)
Pages (from-to)79-92
Number of pages14
JournalThe Journal of Physiology
Volume362
Issue number1
DOIs
StatePublished - May 1 1985

ASJC Scopus subject areas

  • Physiology

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