IPSCs offer a new look at GATA1-trisomy 21 cooperation

Maureen McNulty, John D. Crispino*

*Corresponding author for this work

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.

Original languageEnglish (US)
Pages (from-to)563-564
Number of pages2
JournalCell stem cell
Volume18
Issue number5
DOIs
StatePublished - May 5 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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