Ir gene-controlled response to haptenated hen ovomucoid: Isotypic specificity and dominant nonresponsiveness

Justin B. Starren*, Joseph M. Davie

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We have examined the isotypic pattern of the response of mice to the Ir gene-controlled antigen, dinitrophenyl-ovomucoid (DNP-OM). H-2k mice are high responders (HR); H-2b,d mice are low responders (LR). The isotype patterns of HR and LR strains differ both quantitatively and qualitatively. In the primary response to doses of 20-100 Mg DNP-OM, HR strains produce IgM and IgG antibodies, whereas LR strains produce only IgM. Background genes modify the kinetics of the IgGl primary response in HR strains, but no background was found which allowed an IgG response in a LR strain. In secondary responses, priming with 0.2 μg DNP-OM increases secondary responses in HR strains, and decreases them in LR strains. Control of this response maps to I-A, and is not altered by the bm12 I-Ab mutation. The LR phenotype is dominant in (HR × LR)F1 mice.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalCellular Immunology
Volume104
Issue number1
DOIs
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Ir gene-controlled response to haptenated hen ovomucoid: Isotypic specificity and dominant nonresponsiveness'. Together they form a unique fingerprint.

  • Cite this