Iridocorneal adhesions in patients with the Marfan syndrome

Patrick Arnold, Michael Donohoe, Mark J. Greenwal, Marilyn B. Mets*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Marfan syndrome is an autosomal dominant connective tissue disorder characterized by skeletal, cardiovascular, and ocular anomalies. Ectopia lentis is the most common ocular manifestation. We report an ocular sign not previously described in Marfan syndrome, iridocorneal adhesions secondary to anterior lens subluxation. Three patients with the Marfan syndrome had iridocorneal adhesions on slit-lamp examination. One patient developed adhesions following treatment with pilocarpine. She underwent pars plana vitrectomy and lensectomy in both eyes due to progression of the iridocorneal adhesions. Treatment with miotics rotates the lens-iris diaphragm anteriorly and may contribute to the formation of such adhesions. The two other patients remained stable and did not received lensectomy or vitrectomy. Careful slit-lamp examination of the anterior segment should be conducted in patients with dislocated lenses.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalOphthalmic Genetics
Issue number4
StatePublished - 1999


  • Ectopia lentis
  • Iridocorneal adhesions
  • Marfan syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology
  • Genetics(clinical)


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