Iron: The redox-active center of oxidative stress in Alzheimer disease

Rudy J. Castellani, Paula I. Moreira, Gang Liu, Jon Dobson, George Perry, Mark A. Smith*, Xiongwei Zhu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations

Abstract

Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.

Original languageEnglish (US)
Pages (from-to)1640-1645
Number of pages6
JournalNeurochemical Research
Volume32
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Alzheimer disease
  • Chelation
  • Neurodegeneration
  • Oxidative stress
  • Redox active iron

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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