Iron: The redox-active center of oxidative stress in Alzheimer disease

Rudy J. Castellani; Paula I. Moreira; Gang Liu; Jon Dobson; George Perry; Mark A. Smith; Xiongwei Zhu

doi:10.1007/s11064-007-9360-7

Iron: The redox-active center of oxidative stress in Alzheimer disease

Rudy J. Castellani, Paula I. Moreira, Gang Liu, Jon Dobson, George Perry, Mark A. Smith^*, Xiongwei Zhu

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

170 Scopus citations

Abstract

Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.

Original language	English (US)
Pages (from-to)	1640-1645
Number of pages	6
Journal	Neurochemical Research
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s11064-007-9360-7
State	Published - Oct 2007

Funding

Acknowledgments This study was supported by the National Institutes of Health, the Alzheimer’s Association, and Philip Morris USA Inc., and Philip Morris International.

Keywords

Alzheimer disease
Chelation
Neurodegeneration
Oxidative stress
Redox active iron

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11064-007-9360-7

Cite this

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title = "Iron: The redox-active center of oxidative stress in Alzheimer disease",

abstract = "Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.",

keywords = "Alzheimer disease, Chelation, Neurodegeneration, Oxidative stress, Redox active iron",

author = "Castellani, {Rudy J.} and Moreira, {Paula I.} and Gang Liu and Jon Dobson and George Perry and Smith, {Mark A.} and Xiongwei Zhu",

note = "Funding Information: Acknowledgments This study was supported by the National Institutes of Health, the Alzheimer{\textquoteright}s Association, and Philip Morris USA Inc., and Philip Morris International.",

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doi = "10.1007/s11064-007-9360-7",

language = "English (US)",

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T2 - The redox-active center of oxidative stress in Alzheimer disease

AU - Castellani, Rudy J.

AU - Moreira, Paula I.

AU - Liu, Gang

AU - Dobson, Jon

AU - Perry, George

AU - Smith, Mark A.

AU - Zhu, Xiongwei

N1 - Funding Information: Acknowledgments This study was supported by the National Institutes of Health, the Alzheimer’s Association, and Philip Morris USA Inc., and Philip Morris International.

PY - 2007/10

Y1 - 2007/10

N2 - Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.

AB - Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.

KW - Alzheimer disease

KW - Chelation

KW - Neurodegeneration

KW - Oxidative stress

KW - Redox active iron

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Iron: The redox-active center of oxidative stress in Alzheimer disease

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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