Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator

Y. C. Awasthi*, S. V. Singh, S. K. Goel, J. K. Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Ciprofibrate (2-[4-(2,2-dichlorocyclopropyl) phenoxy]2-methyl propionic acid) which is a hypolipidemic agent and has been shown to cause peroxisome proliferation, non-competitively inhibits glutathione S-transferase activity of rat liver, both in vivo and in vitro. Among all the glutathione S-transferases of rat liver, ligandin is maximally inhibited by ciprofibrate. Studies with the purified glutathione S-transferases of rat liver indicate that the affinities of different subunits of liver enzymes for ciprofibrate are in the order Ya > Yb, Yb' > Yc.

Original languageEnglish (US)
Pages (from-to)1012-1018
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume123
Issue number3
DOIs
StatePublished - Sep 28 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator'. Together they form a unique fingerprint.

  • Cite this