Irritability uniquely predicts prefrontal cortex activation during preschool inhibitory control among all temperament domains: A LASSO approach

Frank A. Fishburn, Christina O. Hlutkowsky, Lisa M. Bemis, Theodore J. Huppert, Lauren S Wakschlag, Susan B. Perlman

Research output: Contribution to journalArticle

Abstract

Temperament, defined as individual variation in the reactivity and regulation of emotional, motor, and attentional processes, has been shown to influence emotional and cognitive development during the preschool period (ages 4–5). While relationships between temperament and neural activity have been investigated previously, these have typically investigated individual temperament dimensions selected ad hoc. Since significant correlations exist between various temperament dimensions, it remains unclear whether these findings would replicate while analyzing all temperament dimensions simultaneously. Using functional near infrared spectroscopy (fNIRS), 4-5-year-old children (N = 118) were administered a Go/No-Go task to assess prefrontal cortex activation during inhibitory control. The relationship between PFC activation and all 15 temperament domains defined by the Children's Behavior Questionnaire (CBQ) was assessed using automatic feature selection via LASSO regression. Results indicate that only the Anger/Frustration dimension was predictive of activation during the inhibitory control task. These findings support previous work showing relationships between irritability and prefrontal activation during executive function and extend those findings by demonstrating the specificity of the activation-irritability relationship among temperament dimensions.

LanguageEnglish (US)
Pages68-77
Number of pages10
JournalNeuroimage
Volume184
DOIs
StatePublished - Jan 1 2019

Fingerprint

Temperament
Prefrontal Cortex
Frustration
Near-Infrared Spectroscopy
Executive Function
Anger
Child Behavior

Keywords

  • Functional near-infrared spectroscopy (fNIRS)
  • Inhibitory control
  • Irritability
  • PFC
  • Preschool
  • Temperament

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Fishburn, Frank A. ; Hlutkowsky, Christina O. ; Bemis, Lisa M. ; Huppert, Theodore J. ; Wakschlag, Lauren S ; Perlman, Susan B. / Irritability uniquely predicts prefrontal cortex activation during preschool inhibitory control among all temperament domains : A LASSO approach. In: Neuroimage. 2019 ; Vol. 184. pp. 68-77.
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Irritability uniquely predicts prefrontal cortex activation during preschool inhibitory control among all temperament domains : A LASSO approach. / Fishburn, Frank A.; Hlutkowsky, Christina O.; Bemis, Lisa M.; Huppert, Theodore J.; Wakschlag, Lauren S; Perlman, Susan B.

In: Neuroimage, Vol. 184, 01.01.2019, p. 68-77.

Research output: Contribution to journalArticle

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