Is in vivo amyloid distribution asymmetric in primary progressive aphasia?

Adam Martersteck*, Christopher Murphy, Alfred Rademaker, Christina Wieneke, Sandra Weintraub, Kewei Chen, M. Marsel Mesulam, Emily Rogalski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We aimed to determine whether 18F-florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left-hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ+) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ+ PPA and an Aβ+ amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group (p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported.

Original languageEnglish (US)
Pages (from-to)496-501
Number of pages6
JournalAnnals of neurology
Volume79
Issue number3
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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