Is intrauterine transfusion associated with diminished fetal growth?

Gregory O. Utter*, Michael L. Socol, Sharon L. Dooley, Scott N. MacGregor, Dietra D. Millard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Studies in animal models and human pregnancies suggest that severe fetal anemia and/or replacement of fetal with adult blood result in decreased pH, increased base deficit, and hyperlactacidemia. Similar changes have been noted in growth-retarded, nonanemic fetuses, and we therefore hypothesized that isoimmunized fetuses requiring intrauterine transfusions might have diminished growth. We longitudinally studied growth patterns in 17 isoimmunized fetuses by noting biparietal diameter and head and abdominal circumeference measurements at each transfusion. The distributions of these measurements above and below the 25th, 50th, and 75th percentiles derived from our general obstetric population were compared at the initial transfusion and the last ultrasonogram performed before delivery. Birth weights also were noted and their distribution around the 25th, 50th, and 75th percentiles was compared to the expected distribution. For each ultrasonographic parameter, the distribution of measurements at the last ultrasonogram before delivery was not significantly different from the distribution at the initial ultrasonogram. The birth weight distribution also was not significantly different than the expected distribution. Thus we were unable to demonstrate slowing of fetal growth in our severely isoimmunized pregnancies.

Original languageEnglish (US)
Pages (from-to)1781-1784
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number6 PART 1
StatePublished - Dec 1990


  • Fetal anemia
  • diminished fetal growth
  • intrauterine transfusion

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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