Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions

Estil Y. Strawn*, David Bick, Amy Swanson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective: To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility. Design: Case report. Setting: Academic medical center. Patient(s): Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient. Intervention(s): Assisted reproductive technology. Main Outcome Measure(s): Neonatal and pediatric morphologic evaluation by geneticists. Result(s): Two children with the morphologic features consistent with the criteria for the diagnosis of BWS. Conclusion(s): Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms.

Original languageEnglish (US)
Pages (from-to)754.e1-754.e2
JournalFertility and Sterility
Volume94
Issue number2
DOIs
StatePublished - Jul 2010

Keywords

  • Beckwith-Wiedemann syndrome
  • assisted reproductive technology
  • subfertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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