TY - JOUR
T1 - Is Kawasaki disease an infectious disorder?
AU - Rowley, Anne H.
N1 - Funding Information:
This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Disease of the National Institutes of Health under grant number R21AR068041, and the National Institute of Allergy and Infectious Diseases under grant number R56AI106030. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. The study was also supported by the Max Goldenberg Foundation and the Center for Kawasaki Disease at the Ann & Robert H. Lurie Children’s Hospital of Chicago.
PY - 2018/1
Y1 - 2018/1
N2 - Although the etiology of Kawasaki disease (KD) is largely unknown, a large body of clinical, epidemiologic, immunologic, pathologic and ultrastructural evidence suggests that an infectious agent triggers a cascade that causes the illness. However, this elusive infectious agent remains unidentified at present. Increasingly sensitive molecular methods for identifying microbial nucleic acids and proteins in tissue samples continue to rapidly emerge, and these methods should be utilized in studies on KD etiology as they become available. Identifying the etiology of this enigmatic disease remains the single most important research goal in the field, and accomplishing this goal is the best means to improve diagnosis, treatment and prevention of this potentially fatal childhood disease.
AB - Although the etiology of Kawasaki disease (KD) is largely unknown, a large body of clinical, epidemiologic, immunologic, pathologic and ultrastructural evidence suggests that an infectious agent triggers a cascade that causes the illness. However, this elusive infectious agent remains unidentified at present. Increasingly sensitive molecular methods for identifying microbial nucleic acids and proteins in tissue samples continue to rapidly emerge, and these methods should be utilized in studies on KD etiology as they become available. Identifying the etiology of this enigmatic disease remains the single most important research goal in the field, and accomplishing this goal is the best means to improve diagnosis, treatment and prevention of this potentially fatal childhood disease.
KW - IgA
KW - acquired immune response
KW - cytotoxic T lymphocytes
KW - interferon
KW - oligoclonal antibodies
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U2 - 10.1111/1756-185X.13213
DO - 10.1111/1756-185X.13213
M3 - Article
C2 - 29105346
AN - SCOPUS:85032980632
VL - 21
SP - 20
EP - 25
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 1
ER -