Abstract
Objective: To test the hypothesis that superficial cartilage composition (T2) is associated with subsequent incidence or worsening of cartilage damage, and deep T2 with that of bone marrow lesions (BMLs) in knees without radiographic osteoarthritis (ROA). Design: A total of 201 knees from the Osteoarthritis Initiative without ROA were included: 78 from the healthy reference cohort, 60 without ROA but with risk factors, and 63 without ROA but with contralateral ROA. Year 1 (Y1) superficial and deep cartilage T2 were derived in the medial and lateral (weightbearing) femur (MF/LF) and tibia (MT/LT), using sagittal multiecho spin echo magnetic resonance images. Cartilage and BMLs were assessed in the medial (MFTJ) and lateral femorotibial joint (LFTJ) at Y1 and 3 years later. Binary logistic regression statistics were applied. Results: Incidence or worsening of cartilage damage was more frequent (MFTJ 15%, LFTJ 13%) than incidence or worsening of BMLs (6.0%, 4.5%). In knees with incident or worsening cartilage lesions in the MF and LT, deep layer T2 in the same plate was elevated (MF, 43.6 ± 4.0 vs. 41.3 ± 3.8 ms, P = 0.047; LT, 33.8 ± 2.3 vs. 32.0 ± 2.2 ms, P = 0.008) compared to those without. In knees with incident or worsening of BMLs in the LFTC and LT, superficial layer T2 was elevated (LFTJ, 49.6 ± 4.8 vs. 46.7 ± 3.1 ms; LT, 47.4 ± 4.9 vs. 44.0 ± 3.3 ms, both Ps = 0.04). Conclusions: Contrary to our hypothesis, increased deep layer cartilage T2 was associated with subsequent worsening of cartilage damage, whereas superficial layer T2 was related to subsequent BML worsening. Yet, this relationship was observed in some, but not in all cartilage plates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 757S-766S |
| Journal | Cartilage |
| Volume | 13 |
| Issue number | 1_suppl |
| DOIs | |
| State | Published - Dec 2021 |
Funding
We would like to thank the OAI participants, OAI investigators, OAI clinical and technical staff, the OAI coordinating center, and the OAI funders for providing this unique public data base. We would further like to thank the German Bundesministerium für Bildung und Forschung (BMBF–01EC1408D–OVERLOAD–PREVOP) for supporting the image analysis. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by a grant from the German Bundesministerium für Bildung und Forschung (Ministry of Education and Science–BMBF–01EC1408D–OVERLOAD–PREVOP) and by a grant from the Paracelsus Medial University research fund (PMU FFF E-13/17/090-WIR). The study and data acquisition was funded by the OAI, a public-private partnership composed of 5 contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the U.S. Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners of the OAI include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript. We would like to thank the OAI participants, OAI investigators, OAI clinical and technical staff, the OAI coordinating center, and the OAI funders for providing this unique public data base. We would further like to thank the German Bundesministerium für Bildung und Forschung (BMBF–01EC1408D–OVERLOAD–PREVOP) for supporting the image analysis. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by a grant from the German Bundesministerium für Bildung und Forschung (Ministry of Education and Science–BMBF–01EC1408D–OVERLOAD–PREVOP) and by a grant from the Paracelsus Medial University research fund (PMU FFF E-13/17/090-WIR). The study and data acquisition was funded by the OAI, a public-private partnership composed of 5 contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the U.S. Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners of the OAI include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript.
Keywords
- MRI
- osteoarthritis
- progression
- risk factors
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Biomedical Engineering
- Immunology and Allergy
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Is Laminar Cartilage Composition as Determined by T2 Relaxometry Associated with Incident and Worsening of Cartilage or Bone Marrow Abnormalities?
Roemer, F. W. (Creator), Eckstein, F. (Creator), Duda, G. (Creator), Guermazi, A. (Creator), Maschek, S. (Creator), Sharma, L. (Creator) & Wirth, W. (Creator), SAGE Journals, 2020
DOI: 10.25384/sage.c.5020553, https://sage.figshare.com/collections/Is_Laminar_Cartilage_Composition_as_Determined_by_T2_Relaxometry_Associated_with_Incident_and_Worsening_of_Cartilage_or_Bone_Marrow_Abnormalities_/5020553
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