Is leptin related to systemic inflammatory response in acute pancreatitis?

Andrés Duarte-Rojo, Ana Lezama-Barreda, María Teresa Ramírez-Iglesias, Mario Peláez-Luna, Guillermo Robles-Díaz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Aim: To evaluate the relationship between leptin and systemic inflammation in acute pancreatitis. Methods: Consecutive patients with acute pancreatitis were included. Body mass index and serum samples were obtained at admission. Leptin, TNF-α, IL-6, -8 and -10 levels were determined by ELISA. Severity was defined according to Atlanta criteria. Results: Fifty-two (29 females) patients were studied. Overall body mass index was similar between mild and severe cases, although women with severe pancreatitis had lower body mass index (P = 0.04) and men showed higher body mass index (P = 0.05). No difference was found in leptin levels regarding the severity of pancreatitis, but higher levels tended to appear in male patients with increased body mass index and severe pancreatitis (P = 0.1). A multivariate analysis showed no association between leptin levels and severity. The strongest cytokine associated with severity was IL-6. Correlations of leptin with another cytokines only showed a trend for IL-8 (P = 0.058). Conclusion: High body mass index was associated with severity only in males, which may be related to android fat distribution. Serum leptin seems not to play a role on the systemic inflammatory response in acute pancreatitis and its association with severe outcome in males might represent a marker of increased adiposity.

Original languageEnglish (US)
Pages (from-to)4392-4396
Number of pages5
JournalWorld Journal of Gastroenterology
Issue number27
StatePublished - Jul 21 2006


  • Acute pancreatitis
  • Cytokines
  • Leptin
  • Obesity
  • Prognosis

ASJC Scopus subject areas

  • Gastroenterology


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