Is the "golden age" of the "golden hour" in sepsis over?

Derek S. Wheeler*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

8 Scopus citations


The so-called "golden hour" of trauma resuscitation has been applied to a number of disease conditions in the intensive care unit (ICU) setting. For example, the "golden hour" as applied to the treatment of critically children and adults with severe sepsis and septic shock is based upon early recognition, early administration of antibiotics, and early reversal of the shock state. However, several clinical studies published over the last decade have called into question this time-honored approach and suggest that overly aggressive fluid resuscitation may cause more harm than good. Perhaps we are finally leaving the "Golden Age" of the "golden hour" and entering a new age in which we are able to use a more personalized approach to fluid management for patients with severe sepsis/septic shock.

Original languageEnglish (US)
Article number447
JournalCritical Care
Issue number1
StatePublished - Dec 29 2015

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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