Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment

Sergejs Berdnikovs, Hiam Abdala-Valencia, Christine McCary, Michelle Somand, Rokeisha Cole, Alex Garcia, Paul Bryce, Joan M. Cook-Mills

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Reports indicate contradictory outcomes for anti-inflammatory functions of the α-tocopherol isoform of vitamin E in clinical studies of asthma and atherosclerosis. These seemingly disparate clinical results are consistent with novel unrecognized properties of isoforms of vitamin E reported in this study. We demonstrate that the isoform D-γ-tocopherol elevates inflammation in experimental asthma. Moreover, D-γ-tocopherol, at as little as 10% the concentration of D-α-tocopherol, ablates the anti-inflammatory benefit of the D-α-tocopherol isoform. A mechanism for these opposing immunoregulatory functions of purified tocopherols at physiological concentrations is not through modulation of expression of several cytokines, chemokines, or adhesion molecules, but is, at least in part, by regulation of endothelial cell signals during leukocyte recruitment. These opposing regulatory functions of vitamin E isoforms have impact on interpretations of vitamin E studies. In summary, our studies with purified tocopherol isoforms alter our understanding of vitamin E regulation of vascular function and asthma.

Original languageEnglish (US)
Pages (from-to)4395-4405
Number of pages11
JournalJournal of Immunology
Volume182
Issue number7
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment'. Together they form a unique fingerprint.

  • Cite this