Isoimmune thrombocytopenia: Coordinated management of mother and infant

Suri Y. Surainder*, Bharathi Bellur, Arshad Choudhry, Thomas J. Chilis, Sudha Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Thrombocytopenia at birth is associated with significant mortality and morbidity. The authors have recently managed 2 siblings with isoimmune thrombocytopenia (IITP). The first, born in 1976, had bilateral cephalhematoma, hyperbilirubinemia, and thrombocytopenia. Platelet count remained low after transfusion of platelet concentrate from a random donor, but rose considerably after transfusion of maternal platelets. The mother was platelet antigen (PLA1) negative and had a high platelet antibody titer. The second child was asymptomatic but developed thrombocytopenia. Management included corticosteroid therapy, exchange transfusion, maternal platelet transfusion, and, later, transfusion of compatible platelets from a maternal uncle. Neither of the babies had purpura. Isoimmune thrombocytopenia in a first-born child is difficult to anticipate. In the subsequent pregnancies after an affected child, close relatives of the mother may be tested for PLA1. Platelet concentrate from a PLA1 negative donor should be available for transfusion at the time of delivery. Blood from the PLA1 negative donor may be utilized for early exchange transfusion.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalObstetrics and gynecology
Issue number1
StatePublished - Jan 1981

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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