Isolated CNS Relapse in 2 High-Risk B-cell Acute Lymphoblastic Leukemia Patients Following SARS-CoV-2 Infection

Shannon C. Walker*, Jennifer R. Reppucci, Mary Ann Thompson, Scott C. Borinstein, Debra L. Friedman, Sara Zarnegar-Lumley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy with a highly favorable overall prognosis. Central nervous system (CNS) relapse of B-ALL is relatively rare and is associated with inferior survival outcomes. We present two patients with B-ALL who developed isolated CNS relapse following confirmed infection with severe acute respiratory syndrome coronavirus 2. In addition to individual and disease factors, we posit that delays in therapy together with immune system modulation because of severe acute respiratory syndrome coronavirus 2 may account for these 2 cases of CNS relapsed B-ALL. We report on this clinical observation to raise awareness of this potential association.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalJournal of pediatric hematology/oncology
Volume44
Issue number3
DOIs
StatePublished - Apr 1 2022

Keywords

  • Acute lymphoblastic leukemia
  • COVID-19
  • Infectious disease
  • Oncology
  • Pediatrics

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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