Isolated CNS vasculitis: Unusual presentation of relapsed ewing sarcoma

Polina Stepensky, Elisha Waldman, Natalia Simanovsky, Iris Fried, Shoshana Revel-Vilk, Igor B. Resnick, Michael Weintraub

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We describe a 12-year-old male who presented with an expressive dysphasia after completion of treatment for unifocal Ewing sarcoma. CNS vasculitis was diagnosed by MRI/MRA and cerebral angiography. Extensive rheumatologic work-up failed to identify an underlying primary process. Restaging studies showed no evidence of tumor. Complete neurologic recovery was achieved on prednisone. Four months later the patient developed overt, extensive metastases, confirmed by biopsy to represent recurrent Ewing sarcoma. Despite intensive therapy the patient succumbed 6 months later. This case demonstrates the unique finding of isolated CNS vasculitis as a presenting sign of Ewing sarcoma.

Original languageEnglish (US)
Pages (from-to)326-328
Number of pages3
JournalPediatric Blood and Cancer
Volume54
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • CNS vasculitis
  • Ewing sarcoma
  • Paraneoplastic phenomena

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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