Abstract
To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)-infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1437-1442 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 195 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 15 2007 |
Funding
Financial support: Funding for the present study was provided by a National Institute on Drug Abuse supplement to the Women’s Interagency HIV Study (WIHS; grant UO1-AI-034993). Funding for hepatitis B and C virological analysis was provided by the National Institute of Allergy and Infectious Diseases (grant RO1-AI-052065 to A.K. and grant RO1-AI-057006 to H.D.S.) and the University of California, San Francisco, Liver Center (grant P30-DK-26743 to M.P.). The WIHS is funded by the National Institute of Allergy and Infectious Diseases, with supplemental funding from the National Cancer Institute and the National Institute on Drug Abuse (grants UO1-AI-35004, UO1-AI-31834, UO1-AI-34994,UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590); funding is also provided by the National Institute of Child Health and Human Development (grant UO1-CH-32632) and the National Center for Research Resources (grants MO1-RR-00071, MO1-RR-00079, and MO1-RR-00083).
ASJC Scopus subject areas
- General Medicine
