Isolated Impairment of Memory Following a Penetrating Lesion of the Fornix Cerebri

Jordan Grafman*, Andrés M. Salazar, Herbert Weingartner, Stephen C. Vance, Christy Ludlow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Persistent memory problems were reported by a 39-year-old man who suffered a penetrating brain wound while serving in Vietnam 15 years earlier. Neuropsychological testing indicated an unusually isolated memory impairment. Computed tomography revealed transection of the columns of the fornix cerebri with no temporal-lobe involvement and minimal thalamic damage. We suggest that the fornix cerebri has a role in the maintenance of information accessibility to both encoding and recall during post-working memory processing and in the organization of verbal information during encoding and/or retrieval for declarative (recall) purposes. These processes are not essential for verbal recognition but can result in decrements on specific laboratory tasks and in social adjustment.

Original languageEnglish (US)
Pages (from-to)1162-1168
Number of pages7
JournalArchives of Neurology
Issue number12
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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