Isolated orbital mass as the primary presentation of a triple-hit lymphoma transformed from a systemic follicular lymphoma

Xiao Yi Zhou, Xinyan Lu, Kirtee Raparia, Yi Hua Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Triple-hit lymphoma is a highly aggressive B-cell lymphoma. We report a case of triple-hit lymphoma transformed from systemic follicular lymphoma (FL) after 9-year remission and presented primarily as an isolated orbital mass without systemic symptoms or lymphadenopathy. Observations: A 58-year-old female presented with intermittent vertical binocular diplopia, left upper eyelid swelling and pain and was found to have a 2.9 cm orbital mass. Histological section revealed a CD10-positive large B-cell lymphoma, consistent with transformation of FL. Fluorescent in situ hybridization (FISH) analysis demonstrated rearrangements involving C-MYC, BCL-2 and BCL-6 genes, indicating a high grade, triple-hit lymphoma. Conclusions and importance: Triple-hit lymphoma transformed from a low-grade lymphoma may initially present as an isolated orbital mass without systemic evidence of transformation. Early recognition of double or triple-hit lymphomas is important since these patients require aggressive chemotherapy.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalAmerican Journal of Ophthalmology Case Reports
Volume10
DOIs
StatePublished - Jun 2018

Keywords

  • Lymphoma
  • Orbital mass
  • Triple-hit lymphoma

ASJC Scopus subject areas

  • Ophthalmology

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