Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.

L. Xu*, J. Xia, Y. Tang, Q. Pan, L. Huang, H. Deng

*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalHunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
Volume22
Issue number6
StatePublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

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