Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.

L. Xu; J. Xia; Y. Tang; Q. Pan; L. Huang; H. Deng

Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.

L. Xu^*, J. Xia, Y. Tang, Q. Pan, L. Huang, H. Deng

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.

Original language	English (US)
Pages (from-to)	471-474
Number of pages	4
Journal	Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
Volume	22
Issue number	6
State	Published - 1997

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.",

abstract = "A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.",

author = "L. Xu and J. Xia and Y. Tang and Q. Pan and L. Huang and H. Deng",

year = "1997",

language = "English (US)",

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pages = "471--474",

journal = "Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University",

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TY - JOUR

T1 - Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.

AU - Xu, L.

AU - Xia, J.

AU - Tang, Y.

AU - Pan, Q.

AU - Huang, L.

AU - Deng, H.

PY - 1997

Y1 - 1997

N2 - A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.

AB - A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.

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EP - 474

JO - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

IS - 6

ER -

Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.

Abstract

ASJC Scopus subject areas

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