Abstract
Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.
| Original language | English (US) |
|---|---|
| Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
| Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
| Publisher | Society for Biomaterials |
| Number of pages | 1 |
| ISBN (Electronic) | 9781510883901 |
| State | Published - Jan 1 2019 |
| Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019 |
Publication series
| Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
|---|---|
| Volume | 40 |
| ISSN (Print) | 1526-7547 |
Conference
| Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
|---|---|
| Country | United States |
| City | Seattle |
| Period | 4/3/19 → 4/6/19 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Biotechnology
- Biomaterials
- Materials Chemistry
Cite this
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Isolation and characterization of inner wall endothelial cells of the schlemm’s canal using a citrate-based polymer. / Ramachandra, Shwetha; Vahabikashi, Amir; Johnson, Mark; Ameer, Guillermo Antonio.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Isolation and characterization of inner wall endothelial cells of the schlemm’s canal using a citrate-based polymer
AU - Ramachandra, Shwetha
AU - Vahabikashi, Amir
AU - Johnson, Mark
AU - Ameer, Guillermo Antonio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.
AB - Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.
UR - http://www.scopus.com/inward/record.url?scp=85065420548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065420548&partnerID=8YFLogxK
M3 - Conference contribution
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
ER -