TY - GEN
T1 - Isolation and characterization of inner wall endothelial cells of the schlemm’s canal using a citrate-based polymer
AU - Ramachandra, Shwetha
AU - Vahabikashi, Amir
AU - Johnson, Mark
AU - Ameer, Guillermo Antonio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.
AB - Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.
UR - http://www.scopus.com/inward/record.url?scp=85065420548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065420548&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065420548
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -