Isolation and characterization of inner wall endothelial cells of the schlemm’s canal using a citrate-based polymer

Shwetha Ramachandra, Amir Vahabikashi, Mark Johnson, Guillermo Antonio Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Glaucoma is defined as an optic neuropathy caused by characteristic damage to the optic nerve subsequently leading to vision loss. It is a significant global health problem and the second leading cause of blindness in both the United Stated and the world, affecting nearly 67 million people worldwide1. The Schlemm’s Canal (SC) is a unique lymphatic like endothelium lined vessel that encircles the cornea through which the aqueous humor is drained to maintain optimum intraocular pressure of 15.5 ± 2.6 mm Hg2,3. Understanding the functional contribution of the endothelia in the SC still remains a very important goal in glaucoma research. The objective of this research is to isolate the SC endothelial cells (SCECs) using a novel laminin derived peptide conjugated to a thermoresponsive hydrogel. The structural and mechanical properties as well as the potential of the hydrogel to isolate the SCECs was evaluated in vitro.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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