Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus

R. T. D'Aquila, W. C. Summers

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.

Original languageEnglish (US)
Pages (from-to)1291-1295
Number of pages5
JournalJournal of virology
Volume61
Issue number4
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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