Abstract
Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1291-1295 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1987 |
ASJC Scopus subject areas
- Insect Science
- Virology
- Microbiology
- Immunology