TY - JOUR
T1 - Isothermal Titration Calorimetry to Investigate Uremic Toxins Adsorbing onto Metal-Organic Frameworks
AU - Kato, Satoshi
AU - Drout, Riki J.
AU - Farha, Omar K.
N1 - Funding Information:
The authors gratefully acknowledge the support of the Nanoporous Materials Genome Center, funded by the US Department of Energy (DOE), Office of Science, Basic Energy Sciences Program (award DE-FG02-17ER16362). We appreciate the artistic support of Zhijie Chen for the schematics depicting the structures of MOFs. We gratefully acknowledge the support of Asahi Kasei Corporation. R.J.D. appreciates the support of the Ryan Fellowship and the International Institute for Nanotechnology. We thank Northwestern University's Keck Biophysics Facility for assistance with ITC data analysis. This work made use of the IMSERC facilities at Northwestern University, which have received support from the NSF (CHE-1048773 and DMR-0521267); the SHyNE Resource (NSF NNCI-1542205); the State of Illinois; and the International Institute for Nanotechnology. S.K. and R.J.D. designed and executed the study. S.K. carried out the majority of the experiments and wrote the manuscript. R.J.D. edited the manuscript. O.K.F. supervised the project. O.K.F. has a financial interest in NuMat Technologies, a startup company that is seeking to commercialize MOFs.
Funding Information:
The authors gratefully acknowledge the support of the Nanoporous Materials Genome Center, funded by the US Department of Energy (DOE), Office of Science, Basic Energy Sciences Program (award DE-FG02-17ER16362 ). We appreciate the artistic support of Zhijie Chen for the schematics depicting the structures of MOFs. We gratefully acknowledge the support of Asahi Kasei Corporation . R.J.D. appreciates the support of the Ryan Fellowship and the International Institute for Nanotechnology . We thank Northwestern University’s Keck Biophysics Facility for assistance with ITC data analysis. This work made use of the IMSERC facilities at Northwestern University, which have received support from the NSF ( CHE-1048773 and DMR-0521267 ); the SHyNE Resource ( NSF NNCI-1542205 ); the State of Illinois ; and the International Institute for Nanotechnology .
Publisher Copyright:
© 2019 The Author(s)
PY - 2020/1/22
Y1 - 2020/1/22
N2 - Recent efforts have examined metal-organic frameworks (MOFs) as sorbents for removing pollutants and trace chemicals, such as pharmaceuticals, from aqueous media. To date, few studies have investigated the energetics of interactions between toxic species and MOF-based sorbents. To this end, we elected to use isothermal titration calorimetry (ITC) to quantify the thermodynamic parameters associated with the adsorption of uremic toxins, namely p-cresyl sulfate and indoxyl sulfate, onto zirconium-based MOFs. NU-1000, a mesoporous MOF comprising a pyrene-based linker, possesses two distinct adsorption sites that display dramatically different enthalpic and entropic parameters. ITC measurements further reveal that a concerted interaction that embodies both favorable enthalpic and entropic contributions is critical for designing a high-capacity MOF-based adsorbent.
AB - Recent efforts have examined metal-organic frameworks (MOFs) as sorbents for removing pollutants and trace chemicals, such as pharmaceuticals, from aqueous media. To date, few studies have investigated the energetics of interactions between toxic species and MOF-based sorbents. To this end, we elected to use isothermal titration calorimetry (ITC) to quantify the thermodynamic parameters associated with the adsorption of uremic toxins, namely p-cresyl sulfate and indoxyl sulfate, onto zirconium-based MOFs. NU-1000, a mesoporous MOF comprising a pyrene-based linker, possesses two distinct adsorption sites that display dramatically different enthalpic and entropic parameters. ITC measurements further reveal that a concerted interaction that embodies both favorable enthalpic and entropic contributions is critical for designing a high-capacity MOF-based adsorbent.
KW - energetics of interactions
KW - isothermal titration calorimetry
KW - metal-organic framework
KW - uremic toxin
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U2 - 10.1016/j.xcrp.2019.100006
DO - 10.1016/j.xcrp.2019.100006
M3 - Article
AN - SCOPUS:85084541353
SN - 2666-3864
VL - 1
JO - Cell Reports Physical Science
JF - Cell Reports Physical Science
IS - 1
M1 - 100006
ER -