Isothiourea-catalyzed enantioselective carboxy group transfer

Caroline Joannesse*, Craig P. Johnston, Carmen Concellón, Carmen Simal, Douglas Philp, Andrew D. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


Transferable skills: Enantiomerically pure isothioureas promote the 0-to C-carboxyl group transfer of oxazolyl carbonates with excellent levels of enantiocontrol (see scheme). The origin of the enantioselectivity of this process was probed mechanistically and rationalized computationally.

Original languageEnglish (US)
Pages (from-to)8914-8918
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
StatePublished - Nov 9 2009


  • Asymmetric catalysis
  • Carboxy group transfer
  • Heterocycles
  • Isothloureas, organocatalysis

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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