TY - JOUR
T1 - JAGGED1 expression is associated with prostate cancer metastasis and recurrence
AU - Santagata, Sandro
AU - Demichelis, Francesca
AU - Riva, Alberto
AU - Varambally, Sooryanarayana
AU - Hofer, Matthias D.
AU - Kutok, Jeffery L.
AU - Kim, Robert
AU - Tang, Jeffery
AU - Montie, James E.
AU - Chinnaiyan, Arul M.
AU - Rubin, Mark A.
AU - Aster, Jon C.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Recent studies suggest that NOTCH signaling can promote epithelial-mesenchymal transitions and augment signaling through AKT, an important growth and survival pathway in epithelial cells and prostate cancer in particular. Here we show that JAGGED1, a NOTCH receptor ligand, is significantly more highly expressed in metastatic prostate cancer as compared with localized prostate cancer or benign prostatic tissues, based on immunohistochemical analysis of JAGGED1 expression in human tumor samples from 154 men. Furthermore, high JAGGED1 expression in a subset of clinically localized tumors was significantly associated with recurrence, independent of other clinical parameters. These findings support a model in which dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers.
AB - Recent studies suggest that NOTCH signaling can promote epithelial-mesenchymal transitions and augment signaling through AKT, an important growth and survival pathway in epithelial cells and prostate cancer in particular. Here we show that JAGGED1, a NOTCH receptor ligand, is significantly more highly expressed in metastatic prostate cancer as compared with localized prostate cancer or benign prostatic tissues, based on immunohistochemical analysis of JAGGED1 expression in human tumor samples from 154 men. Furthermore, high JAGGED1 expression in a subset of clinically localized tumors was significantly associated with recurrence, independent of other clinical parameters. These findings support a model in which dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers.
UR - http://www.scopus.com/inward/record.url?scp=4944241544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4944241544&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-04-2500
DO - 10.1158/0008-5472.CAN-04-2500
M3 - Article
C2 - 15466172
AN - SCOPUS:4944241544
SN - 0008-5472
VL - 64
SP - 6854
EP - 6857
JO - Cancer Research
JF - Cancer Research
IS - 19
ER -
