JAK2 and JMJD1C activate NFE2 in MPNs

John D. Crispino

Research output: Contribution to journalReview articlepeer-review


Overexpression of nuclear factor erythroid 2 (NFE2) is commonly observed in the myeloproliferative neoplasms (MPNs), especially polycythemia vera (PV) and primary myelofibrosis,1,2 but the mechanism that drives this feature has been unclear. In this issue of Blood, Peeken et al reveal a 2-pronged epigenetic pathway that promotes NFE2 overexpression and disease3

Original languageEnglish (US)
Pages (from-to)1998-1999
Number of pages2
Issue number18
StatePublished - May 3 2018

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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