JAKing up AML1-ETO

John D. Crispino*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations


In this issue of Blood, Chou et al 1 and Pulikkan et al 2 reveal that the (8;21)(q22;q22) translocation product AML1-ETO (RUNX1-RUNX1T1) leads to enhanced JAK/STAT signaling downstream of myeloproliferative leukemia (MPL) virus, which in turn contributes to increased survival of tumor cells. Hijacking of the JAK/STAT pathway through up-regulation of wild-type MPL is a new paradigm for hematologic malignancies.

Original languageEnglish (US)
Pages (from-to)703-704
Number of pages2
Issue number4
StatePublished - Jul 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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