Abstract
Combination chemotherapy administering multiple chemo agents is widely exploited for the treatment of various cancers in the clinic. Specially for hepatocellular carcinoma (HCC), one of the most common malignancies, a coadministration of combinational cytostatic multikinase inhibitors and cytotoxic chemo agents has been suggested as a potential curative approach. Here, Janus microcarriers are developed for the controlled local combination chemotherapy of HCC. The Janus microcarriers are composed of a polycaprolactone (PCL) compartment and a magnetic nanoparticle-loaded poly(lactide-co-glycolic acid) (PLGA) compartment which contains hydrophobic regorafenib and hydrophilic doxorubicin, respectively. Exploiting the magnetic anisotropy, rotational motion of the Janus microcarriers is controlled with a magnetic field, which enables the active corelease of dual chemo agents. Furthermore, Janus microcarriers exhibit magnetic resonance (MR) contrast effect, supporting the successful transcatheter intra-arterial delivery of the combination chemo agents loaded in the microcarriers to the targeted tumor. This Janus microcarrier potentially serves as a general combinational chemotherapeutic platform for the codelivery of various combinations of multichemo agents.
| Original language | English (US) |
|---|---|
| Article number | 1901384 |
| Journal | Advanced Functional Materials |
| Volume | 29 |
| Issue number | 26 |
| DOIs | |
| State | Published - Jun 27 2019 |
Funding
S.C. and N.G.M. contributed equally to this work. This work was supported by grants R21CA173491, R01CA218659, and R01EB026207 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering. The authors also appreciate a partial support from the National Research Foundation (NRF) of Korea (NRF-2015K1A1A2033054).
Keywords
- Janus microcarriers
- cancer therapy
- drug release
- liver cancer
- magnetic response
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- Condensed Matter Physics
