Janus Microcarriers for Magnetic Field-Controlled Combination Chemotherapy of Hepatocellular Carcinoma

Soojeong Cho, Nam Gi Min, Wooram Park, Shin Hyun Kim*, Dong Hyun Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Combination chemotherapy administering multiple chemo agents is widely exploited for the treatment of various cancers in the clinic. Specially for hepatocellular carcinoma (HCC), one of the most common malignancies, a coadministration of combinational cytostatic multikinase inhibitors and cytotoxic chemo agents has been suggested as a potential curative approach. Here, Janus microcarriers are developed for the controlled local combination chemotherapy of HCC. The Janus microcarriers are composed of a polycaprolactone (PCL) compartment and a magnetic nanoparticle-loaded poly(lactide-co-glycolic acid) (PLGA) compartment which contains hydrophobic regorafenib and hydrophilic doxorubicin, respectively. Exploiting the magnetic anisotropy, rotational motion of the Janus microcarriers is controlled with a magnetic field, which enables the active corelease of dual chemo agents. Furthermore, Janus microcarriers exhibit magnetic resonance (MR) contrast effect, supporting the successful transcatheter intra-arterial delivery of the combination chemo agents loaded in the microcarriers to the targeted tumor. This Janus microcarrier potentially serves as a general combinational chemotherapeutic platform for the codelivery of various combinations of multichemo agents.

Original languageEnglish (US)
Article number1901384
JournalAdvanced Functional Materials
Volume29
Issue number26
DOIs
StatePublished - Jun 27 2019

Keywords

  • Janus microcarriers
  • cancer therapy
  • drug release
  • liver cancer
  • magnetic response

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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