JC virus granule cell neuronopathy as AIDS-presenting illness

Simon Grandjean Lapierre*, Xin Dang, Danielle Gilbert, Sylvie Lauzier, Igor J. Koralnik, Louiselle Leblanc

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

JC virus is the etiological agent of progressive multifocal leukoencephalopathy, a white matter demyelinating disease that mostly affects immunocompromised patients. JC virus can also infect neurons and meningeal cells and cause encephalitis, meningitis and granule cell neuronopathy. We report a patient with JC virus granule cell neuronopathy, without concomitant progressive multifocal leukoencephalopathy, presenting as inaugural acquired immune deficiency syndrome-related illness. This patient's human immunodeficiency virus infection remained undiagnosed for several months after neurological symptoms onset. We review JC virus pathophysiology, clinical manifestations, treatment and prognosis, and emphasize the importance of considering human immunodeficiency virus infection and related opportunistic infections in the differential diagnosis of new-onset isolated cerebellar disease.

Original languageEnglish (US)
Pages (from-to)466-469
Number of pages4
JournalCanadian Journal of Neurological Sciences
Volume45
Issue number4
DOIs
StatePublished - Jul 1 2018

Keywords

  • Demyelination
  • Granule cell neuronopathy
  • HIV
  • JC virus
  • Neuroimaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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