JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

David N. Soleimani-Meigooni; Katherine E. Schwetye; Maria Reyes Angeles; Caroline F. Ryschkewitsch; Eugene O. Major; Xin Dang; Igor J. Koralnik; Robert E. Schmidt; David B. Clifford; F. Matthew Kuhlmann; Robert C. Bucelli

doi:10.1007/s13365-016-0465-0

JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

David N. Soleimani-Meigooni, Katherine E. Schwetye, Maria Reyes Angeles, Caroline F. Ryschkewitsch, Eugene O. Major, Xin Dang, Igor J. Koralnik, Robert E. Schmidt, David B. Clifford, F. Matthew Kuhlmann, Robert C. Bucelli^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Journal of neurovirology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s13365-016-0465-0
State	Published - Feb 1 2017

Keywords

Cerebellar ataxia
Granule cell neuronopathy
Il-7
JC virus
Lymphopenia

ASJC Scopus subject areas

Clinical Neurology
Neurology
Cellular and Molecular Neuroscience
Virology

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Soleimani-Meigooni, D. N., Schwetye, K. E., Angeles, M. R., Ryschkewitsch, C. F., Major, E. O., Dang, X., Koralnik, I. J., Schmidt, R. E., Clifford, D. B., Kuhlmann, F. M., & Bucelli, R. C. (2017). JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. Journal of neurovirology, 23(1), 141-146. https://doi.org/10.1007/s13365-016-0465-0

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title = "JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7",

abstract = "JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.",

keywords = "Cerebellar ataxia, Granule cell neuronopathy, Il-7, JC virus, Lymphopenia",

author = "Soleimani-Meigooni, {David N.} and Schwetye, {Katherine E.} and Angeles, {Maria Reyes} and Ryschkewitsch, {Caroline F.} and Major, {Eugene O.} and Xin Dang and Koralnik, {Igor J.} and Schmidt, {Robert E.} and Clifford, {David B.} and Kuhlmann, {F. Matthew} and Bucelli, {Robert C.}",

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doi = "10.1007/s13365-016-0465-0",

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Soleimani-Meigooni, DN, Schwetye, KE, Angeles, MR, Ryschkewitsch, CF, Major, EO, Dang, X, Koralnik, IJ, Schmidt, RE, Clifford, DB, Kuhlmann, FM & Bucelli, RC 2017, 'JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7', Journal of neurovirology, vol. 23, no. 1, pp. 141-146. https://doi.org/10.1007/s13365-016-0465-0

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T1 - JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

AU - Soleimani-Meigooni, David N.

AU - Schwetye, Katherine E.

AU - Angeles, Maria Reyes

AU - Ryschkewitsch, Caroline F.

AU - Major, Eugene O.

AU - Dang, Xin

AU - Koralnik, Igor J.

AU - Schmidt, Robert E.

AU - Clifford, David B.

AU - Kuhlmann, F. Matthew

AU - Bucelli, Robert C.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.

AB - JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.

KW - Cerebellar ataxia

KW - Granule cell neuronopathy

KW - Il-7

KW - JC virus

KW - Lymphopenia

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JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

Abstract

Keywords

ASJC Scopus subject areas

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